HMS Connectomics Core
The goal of the HMS Connectomics Core is to help researchers acquire, align, segment, proofread, and annotate large-scale maps of cell-cell interactions using volumetric electron microscopy (EM), genetically encoded cell-type-specific EM tags, trans-synaptic viral tracing, machine learning algorithms, and advanced statistical methods.
Currently, we assist groups with analysis of existing large-scale electron and X-ray microscopy datasets. This involves deployment of infrastructure, computer workstations, and software resources for connectomic data analysis.
Latest Publications
2022
Tri Nguyen, Logan Thomas, Jeff Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David Hildebrand, Jan Funke, Wade Regehr, and Wei-Chung Allen Lee. 2022. “Structured Cerebellar Connectivity Supports Resilient Pattern Separation”. Nature. doi:10.1038/s41586-022-05471-w
Tri Nguyen, Logan Thomas, Jeff Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David Hildebrand, Jan Funke, Wade Regehr, and Wei-Chung Allen Lee. 2022. “Structured Cerebellar Connectivity Supports Resilient Pattern Separation”. Nature. doi:10.1038/s41586-022-05471-w
Jenny Lu, Amir Behbahani, Lydia Hamburg, Elena Westeinde, Paul Dawson, Cheng Lyu, Gaby Maimon, Michael Dickinson, Shaul Druckmann, and Rachel Wilson. 2022. “Transforming Representations of Movement from Body- to World-Centric Space”. Nature, 601, 7891, Pp. 98-104. doi:10.1038/s41586-021-04191-x
Jenny Lu, Amir Behbahani, Lydia Hamburg, Elena Westeinde, Paul Dawson, Cheng Lyu, Gaby Maimon, Michael Dickinson, Shaul Druckmann, and Rachel Wilson. 2022. “Transforming Representations of Movement from Body- to World-Centric Space”. Nature, 601, 7891, Pp. 98-104. doi:10.1038/s41586-021-04191-x
Akira Mamiya, Pralaksha Gurung, Igor Siwanowicz, Anne Sustar, Chenghao Chen, Jasper Phelps, Aaron Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Natasha Mhatre, and John C. Tuthill. 2022. “Biomechanical Origins of Proprioceptive Maps in the Drosophila Leg”. BioRxiv
Akira Mamiya, Pralaksha Gurung, Igor Siwanowicz, Anne Sustar, Chenghao Chen, Jasper Phelps, Aaron Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Natasha Mhatre, and John C. Tuthill. 2022. “Biomechanical Origins of Proprioceptive Maps in the Drosophila Leg”. BioRxiv
Aaron Kuan, Giulio Bondanelli, Laura Driscoll, Julie Han, Minsu Kim, David Hildebrand, Brett Graham, Logan Thomas, Stefano Panzeri, Christopher Harvey, and Wei-Chung Allen Lee. 2022. “Synaptic Wiring Motifs in Posterior Parietal Cortex Support Decision-Making”. BioRxiv
Aaron Kuan, Giulio Bondanelli, Laura Driscoll, Julie Han, Minsu Kim, David Hildebrand, Brett Graham, Logan Thomas, Stefano Panzeri, Christopher Harvey, and Wei-Chung Allen Lee. 2022. “Synaptic Wiring Motifs in Posterior Parietal Cortex Support Decision-Making”. BioRxiv
2021
Chenghao Chen, Sweta Agrawal, Brandon Mark, Akira Mamiya, Anne Sustar, Jasper Phelps, Wei-Chung Allen Lee, Barry Dickson, Gwyneth Card, and John Tuthill. 2021. “Functional Architecture of Neural Circuits for Leg Proprioception in Drosophila”. Curr Biol, 31, 23, Pp. 5163-5175.e7. doi:10.1016/j.cub.2021.09.035
Chenghao Chen, Sweta Agrawal, Brandon Mark, Akira Mamiya, Anne Sustar, Jasper Phelps, Wei-Chung Allen Lee, Barry Dickson, Gwyneth Card, and John Tuthill. 2021. “Functional Architecture of Neural Circuits for Leg Proprioception in Drosophila”. Curr Biol, 31, 23, Pp. 5163-5175.e7. doi:10.1016/j.cub.2021.09.035