# HMS Connectomics Core The goal of the HMS Connectomics Core is to help researchers acquire, align, segment, proofread, and annotate large-scale maps of cell-cell interactions using volumetric electron microscopy (EM), genetically encoded cell-type-specific EM tags, trans-synaptic viral tracing, machine learning algorithms, and advanced statistical methods. Currently, we assist groups with analysis of existing large-scale electron and X-ray microscopy datasets. This involves deployment of infrastructure, computer workstations, and software resources for connectomic data analysis. ![FANG dataset](/sites/g/files/omnuum8521/files/styles/hwp_21_9__1920x825/public/connectomics/files/jaspercellpaperfig.png?h=1e916371&itok=P8Mt8Fl6) ## Latest Publications Download 5 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=5&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1658440&content_filter%5B1%5D=1655166&content_filter%5B2%5D=1655165&content_filter%5B3%5D=1655164&content_filter%5B4%5D=1655163&&format=ris) ### 2022 Tri Nguyen, Logan Thomas, Jeff Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David Hildebrand, Jan Funke, Wade Regehr, and Wei-Chung Allen Lee. 2022. “[Structured Cerebellar Connectivity Supports Resilient Pattern Separation](/publications/structured-cerebellar-connectivity-supports-resilient-pattern-separation)”. Nature. doi:10.1038/s41586-022-05471-w Tri Nguyen, Logan Thomas, Jeff Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David Hildebrand, Jan Funke, Wade Regehr, and Wei-Chung Allen Lee. 2022. “[Structured Cerebellar Connectivity Supports Resilient Pattern Separation](/publications/structured-cerebellar-connectivity-supports-resilient-pattern-separation)”. Nature. doi:10.1038/s41586-022-05471-w - add\_circle do\_not\_disturb\_on Abstract The cerebellum is thought to help detect and correct errors between intended and executed commands1,2 and is critical for social behaviours, cognition and emotion3-6. Computations for motor control must be performed quickly to correct errors in real time... Jenny Lu, Amir Behbahani, Lydia Hamburg, Elena Westeinde, Paul Dawson, Cheng Lyu, Gaby Maimon, Michael Dickinson, Shaul Druckmann, and Rachel Wilson. 2022. “[Transforming Representations of Movement from Body- to World-Centric Space](/publications/transforming-representations-movement-body-world-centric-space-0)”. Nature, 601, 7891, Pp. 98-104. doi:10.1038/s41586-021-04191-x Jenny Lu, Amir Behbahani, Lydia Hamburg, Elena Westeinde, Paul Dawson, Cheng Lyu, Gaby Maimon, Michael Dickinson, Shaul Druckmann, and Rachel Wilson. 2022. “[Transforming Representations of Movement from Body- to World-Centric Space](/publications/transforming-representations-movement-body-world-centric-space-0)”. Nature, 601, 7891, Pp. 98-104. doi:10.1038/s41586-021-04191-x - add\_circle do\_not\_disturb\_on Abstract When an animal moves through the world, its brain receives a stream of information about the body's translational velocity from motor commands and sensory feedback signals. These incoming signals are referenced to the body, but ultimately, they must be... Akira Mamiya, Pralaksha Gurung, Igor Siwanowicz, Anne Sustar, Chenghao Chen, Jasper Phelps, Aaron Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Natasha Mhatre, and John C. Tuthill. 2022. “[Biomechanical Origins of Proprioceptive Maps in the Drosophila Leg](https://doi.org/10.1101/2022.08.08.503192)”. BioRxiv Akira Mamiya, Pralaksha Gurung, Igor Siwanowicz, Anne Sustar, Chenghao Chen, Jasper Phelps, Aaron Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Natasha Mhatre, and John C. Tuthill. 2022. “[Biomechanical Origins of Proprioceptive Maps in the Drosophila Leg](https://doi.org/10.1101/2022.08.08.503192)”. BioRxiv - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2022.08.08.503192v1) Proprioception, the sense of body position and movement, is essential for effective motor control. Because proprioceptive sensory neurons are embedded in complex and dynamic tissues, it has been challenging to understand how they sense and encode... - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2022.08.08.503192v1) Aaron Kuan, Giulio Bondanelli, Laura Driscoll, Julie Han, Minsu Kim, David Hildebrand, Brett Graham, Logan Thomas, Stefano Panzeri, Christopher Harvey, and Wei-Chung Allen Lee. 2022. “[Synaptic Wiring Motifs in Posterior Parietal Cortex Support Decision-Making](https://doi.org/10.1101/2022.04.13.488176)”. BioRxiv Aaron Kuan, Giulio Bondanelli, Laura Driscoll, Julie Han, Minsu Kim, David Hildebrand, Brett Graham, Logan Thomas, Stefano Panzeri, Christopher Harvey, and Wei-Chung Allen Lee. 2022. “[Synaptic Wiring Motifs in Posterior Parietal Cortex Support Decision-Making](https://doi.org/10.1101/2022.04.13.488176)”. BioRxiv - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2022.04.13.488176v1) The posterior parietal cortex (PPC) exhibits choice-selective activity during perceptual decision-making tasks. However, it is not known how this selective activity arises from the underlying synaptic connectivity. Here, we combined virtual reality... - [ descriptionPublisher's Version](https://www.biorxiv.org/content/10.1101/2022.04.13.488176v1) ### 2021 Chenghao Chen, Sweta Agrawal, Brandon Mark, Akira Mamiya, Anne Sustar, Jasper Phelps, Wei-Chung Allen Lee, Barry Dickson, Gwyneth Card, and John Tuthill. 2021. “[Functional Architecture of Neural Circuits for Leg Proprioception in Drosophila](/publications/functional-architecture-neural-circuits-leg-proprioception-drosophila)”. Curr Biol, 31, 23, Pp. 5163-5175.e7. doi:10.1016/j.cub.2021.09.035 Chenghao Chen, Sweta Agrawal, Brandon Mark, Akira Mamiya, Anne Sustar, Jasper Phelps, Wei-Chung Allen Lee, Barry Dickson, Gwyneth Card, and John Tuthill. 2021. “[Functional Architecture of Neural Circuits for Leg Proprioception in Drosophila](/publications/functional-architecture-neural-circuits-leg-proprioception-drosophila)”. Curr Biol, 31, 23, Pp. 5163-5175.e7. doi:10.1016/j.cub.2021.09.035 - add\_circle do\_not\_disturb\_on Abstract To effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these... [ More arrow\_circle\_right ](/publications)